R&D 사업소개
세포생물 상호간, 소통시스템을 이용한 의약품 연구/개발
Prokaryotes and eukaryotes have coexisted for many years, during which time they have been exposed to the signals produced and released by the other. The organisms of two kingdoms have also learnt to sense their various molecules including QS signals to influence gene expression and behavior in a process called inter- kingdom signaling
‘원핵생물’ 과 ‘진핵생물’ 은 오랫동안 공존해왔으며, 다른 생명체에 의해 생성되고 방출되는 신호에 노출되어 왔습니다.For cell- to-cell communication, these bacteria employ the quorum sensing (QS) system to pass on information of the density of the bacterial population and collectively switch on virulence factor production, biofilm formation, and resistance development. Thus, QS allows bacteria to behave as a community to perform tasks which would be impossible for individual cells, e.g., to overcome defense and immune systems and establish infections in higher organisms.
‘정족수 감지’ (QUORUM SENSING)는 박테리아가 개별 세포에서 불가능한 작업을 수행하기 위해 공동체로 행동할 수 있도록 합니다.R&D 핵심연구영역
세포생물과 사람의 소통시스템을 이용한 의약품 연구/개발
Quorum-sensing (QS) system is a rapidly developing field in which we are gradually expanding our understanding about how bacteria communicate with each other and regulate their activities in bacterial sociality.
‘정족수 감지’ (QUORUM SENSING) 시스템은 빠르게 발전하고 있는 분야로 박테리아가 서로 소통하고 세균의 집단적 활동을 조절하는 방법에 대한 연구 등으로 확대되고 있습니다.researchers focused on eliminating bacteria using conventional antimicrobials. In the 1950s, success in rescuing Clostridium difficile infection using fecal microbiota transplantation (FMT) introduced a new perspective, i.e., introduction of a mixed microbial community, instead of eliminating specific bacteria, may benefit the host in fighting microbial infection. Around the same time, a phenomenon of intercellular communication in specific bacterial communities was discovered
과거의 연구자들은 기존의 항생제를 사용하여 박테리아를 제거하는 데 초점을 맞추었습니다.연구를 통하여 새로운 관점, 즉 특정 박테리아를 제거하는 대신 혼합 미생물 군집을 도입하면 미생물 감염과 싸우는 데 도움이 될 수 있습니다.